Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

Abstract

Antibody drug conjugates (ADCs) have emerged as an important pharmaceutical class of drugs designed to harness the specificity of antibodies with the potency of small molecule therapeutics. The three main components of ADCs are the antibody, the linker, and the payload; the majority of early work focused intensely on improving the functionality of these… (More)
DOI: 10.1208/s12248-014-9710-8

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Cite this paper

@article{McCombs2014AntibodyDC, title={Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry}, author={Jessica R. McCombs and Shawn C Owen}, journal={The AAPS Journal}, year={2014}, volume={17}, pages={339-351} }