Antibody‐dependent enhancement of viral infection: molecular mechanisms and in vivo implications

@article{Takada2003AntibodydependentEO,
  title={Antibody‐dependent enhancement of viral infection: molecular mechanisms and in vivo implications},
  author={Ayato Takada and Yoshihiro Kawaoka},
  journal={Reviews in Medical Virology},
  year={2003},
  volume={13}
}
Besides the common receptor/coreceptor‐dependent mechanism of cellular attachment, some viruses rely on antiviral antibodies for their efficient entry into target cells. This mechanism, known as antibody‐dependent enhancement (ADE) of viral infection, depends on the cross‐linking of complexes of virus–antibody or virus–activated complement components through interaction with cellular molecules such as Fc receptors or complement receptors, leading to enhanced infection of susceptible cells… Expand

Paper Mentions

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The results demonstrate that the newly emerged pandemic H1N1 Influenza A virus infection of cells of the hematopoietic lineage may be enhanced by the presence of some human sera and the biological significance and molecular mechanisms underlying serum-mediated ADE infection of influenza virus. Expand
Fc receptors in antibody‐dependent enhancement of viral infections
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In vitro studies confirm in vitro studies confirming ADE as a feature of infection for a growing number of viruses and challenges remain in understanding the multilayered molecular mechanisms of ADE and its effect on viral pathogenesis. Expand
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A neutralizing monoclonal antibody, which targets the receptor-binding domain of Middle East respiratory syndrome (MERS) coronavirus spike, mediates viral entry using pseudovirus entry and biochemical assays, and results showed that MAb binds to the virus surface spike, allowing it to undergo conformational changes and become prone to proteolytic activation. Expand
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The results suggest that C1q- mediated ADE of EBOV infection is simply caused by increased attachment of virus particles to the cell surface, which is distinct from the mechanism of FcR-mediated ADE requiring intracellular signaling to promote phagocytosis/macropinocytotic. Expand
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  • R. Kulkarni
  • Biology
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  • 2019
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TLDR
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Neutralized Adenovirus-Immune Complexes Can Mediate Effective Gene Transfer via an Fc Receptor-Dependent Infection Pathway
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It is hypothesized that Ad-immune complexes likely contain viable Ad vectors which, although no longer capable of gaining access to receptors on target cells, may be able to express transgenes in cells bearing Fc receptors for immunoglobulins, i.e., that antibody-based “neutralization” of Ad vectors may be circumvented by the Fc receptor pathway. Expand
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