Antibody‐Drug Conjugates for the Treatment of Cancer

@article{Flygare2013AntibodyDrugCF,
  title={Antibody‐Drug Conjugates for the Treatment of Cancer},
  author={Johan Flygare and Thomas H. Pillow and Paul Adrian Aristoff},
  journal={Chemical Biology \& Drug Design},
  year={2013},
  volume={81}
}
With over 20 antibody‐drug conjugates in clinical trials as well as a recently FDA‐approved drug, it is clear that this is becoming an important and viable approach for selectively delivering highly cytotoxic agents to tumor cells while sparing normal tissue. This review discusses the critical aspects for this approach with an emphasis on the properties of the linker between the antibody and the cytotoxic payload that are required for an effective antibody‐drug conjugate. Different linkers are… 

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