Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration.

@article{Medei2008AntibodiesWB,
  title={Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration.},
  author={Emiliano Hor{\'a}cio Medei and Jose Hamilton Matheus Nascimento and Roberto Coury Pedrosa and Luciane Claudia Barcellos and Masako Oya Masuda and Serge Sicouri and Marcelo V{\'i}ctor Elizari and Antonio Carlos Campos Campos de Carvalho},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  year={2008},
  volume={10 7},
  pages={868-76}
}
AIMS The aim of this study was to investigate whether the sera from chronic chagasic patients (CChPs) with beta-1 adrenergic activity (Ab-beta) can modulate ventricular repolarization. Beta-adrenergic activity has been described in CChP. It increases the L-type calcium current and heart rate in isolated hearts, but its effects on ventricular repolarization has not been described. METHODS AND RESULTS In isolated rabbit hearts, under pacing condition, QT interval was measured under Ab-beta… CONTINUE READING

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