Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.

@article{Snir2010AntibodiesTS,
  title={Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.},
  author={Omri Snir and Mona Widhe and Monika Hermansson and Caroline von Spee and Johan Lindberg and S. R. Hensen and Karin Lundberg and Ake Engstr{\"o}m and Patrick J. W. Venables and Ren{\'e} E M Toes and Rikard Holmdahl and Katherine A. Siminovitch and Vivianne Malmstr{\"o}m},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 1},
  pages={
          44-52
        }
}
OBJECTIVE High titers of specific anti-citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well-defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their… CONTINUE READING

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