Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications

  title={Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications},
  author={{\'A}lvaro Cobo-Calvo and Maria Sep{\'u}lveda and Rapha{\"e}l Bernard-Valnet and Anne Ruiz and David Brassat and Sergio Mart{\'i}nez-Y{\'e}lamos and Albert Saiz and Romain Marignier},
  journal={Multiple Sclerosis Journal},
  pages={312 - 319}
Objective: We aimed to investigate the frequency and clinical significance of antibodies to myelin oligodendrocyte glycoprotein (MOG-abs) in patients who presented with a first episode of seronegative aquaporin 4 antibody (AQP4-ab) longitudinally extensive transverse myelitis (LETM). Methods: Epidemiological, clinical, and paraclinical data of 56 patients from three European centres were analysed. Patients were retrospectively tested for MOG-abs and AQP4-abs, by cell-based assays. Findings… 

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