Antibodies to myelin basic protein and measles virus in multiple sclerosis: Precursor frequency analysis of the antibody producing B cells

@article{Jingwu1991AntibodiesTM,
  title={Antibodies to myelin basic protein and measles virus in multiple sclerosis: Precursor frequency analysis of the antibody producing B cells},
  author={Z. Jingwu and Paula Henderikx and Y. Chin and J. Raus},
  journal={Journal of Neuroimmunology},
  year={1991},
  volume={35}
}
Antibody-producing B lymphocytes were polyclonally activated and transformed, by Epstein-Barr virus (EBV), into multiple B lymphoblastoid cell lines in a microculture system. The frequencies of B precursor cells producing antibodies to myelin basic protein (MBP) and measles virus were analyzed in peripheral blood of patients with multiple sclerosis (MS) and control subjects. Measles virus-specific B cells were detected at a significantly higher frequency in MS patients (n = 10, P less than 0… CONTINUE READING