Antibodies to laminin in Chagas' disease

  title={Antibodies to laminin in Chagas' disease},
  author={A Szarfman and Victor P. Terranova and Stephen I. Rennard and Jean Michel Foidart and M de Fatima Lima and Jonathan I. Scheinman and George Robert Martin},
  journal={The Journal of Experimental Medicine},
  pages={1161 - 1171}
We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose… CONTINUE READING


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