Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.

@article{Zhu2001AntibodiesTH,
  title={Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.},
  author={Jun-Yi Zhu and Arshed A Quyyumi and David Rott and Gyorgy Csako and Henry P Wu and Julian P. J. Halcox and Stephen E. Epstein},
  journal={Circulation},
  year={2001},
  volume={103 8},
  pages={1071-5}
}
BACKGROUND Antibodies to mycobacterial heat-shock protein (HSP) 65 have been reported to be associated with carotid artery thickening. We examined whether antibodies to human HSP60 are associated with the risk of coronary artery disease (CAD). METHODS AND RESULTS Blood samples from 391 patients (62% men, mean age 57 years) being evaluated for CAD by coronary angiography were tested for IgG antibodies to human HSP60 by ELISA. We found that 75% of the study subjects had anti-HSP60 antibodies… CONTINUE READING

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