Antibodies to extractable nuclear antigens in antinuclear antibody-negative samples.

@article{Bossuyt2005AntibodiesTE,
  title={Antibodies to extractable nuclear antigens in antinuclear antibody-negative samples.},
  author={X. Bossuyt and A. Luyckx},
  journal={Clinical chemistry},
  year={2005},
  volume={51 12},
  pages={
          2426-7
        }
}
Antibodies to extractable nuclear antigens (ENAs)—SSA, SSB, U1RNP, Sm, Scl-70, and Jo-1—are clinically important in patients with systemic rheumatic diseases. Indirect immunofluorescence (IIF) with HEp-2 cells is a common initial screening test for detection of antinuclear antibodies (ANAs) and antibodies to ENAs. IIF-positive samples are further screened with more specific assays, but few studies have addressed the value of this cascade testing (1)(2). Although screening with conventional HEp… Expand

Tables and Topics from this paper

Second generation analysis of antinuclear antibody (ANA) by combination of screening and confirmatory testing
Screening for connective tissue disease-associated antibodies by automated immunoassay
Antinuclear Antibody Tests.
Comparison of the clinical utility of the Elia CTD Screen to indirect immunofluorescence on Hep-2 cells
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