Antibodies to cytokeratin and vimentin in testicular tumour diagnosis

  title={Antibodies to cytokeratin and vimentin in testicular tumour diagnosis},
  author={Frans Ramaekers and Wout F. J. Feitz and Olof Moesker and Gert Schaart and Chester Herman and Frans Debruyne and Peter Vooijs},
  journal={Virchows Archiv A},
Thirteen primary and metastatic testicular germ cell tumours, including classical and anaplastic seminomas, and non-seminomatous testicular tumours were examined for their intermediate filament protein (IFP) types. The seminomas were shown to react with a monoclonal and a polyclonal antibody to bovine lens vimentin, while non-seminomatous germ cell tumours were strongly positive for a polyclonal and a monoclonal antibody to cytokeratin. In one case of seminoma with elevated serum levels ofβHCG… CONTINUE READING
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