Antibodies to a synthetic peptide can be used to distinguish between muscarinic acetylcholine receptor binding sites in brain and heart.

@article{Luthin1988AntibodiesTA,
  title={Antibodies to a synthetic peptide can be used to distinguish between muscarinic acetylcholine receptor binding sites in brain and heart.},
  author={Gary R Luthin and Joseph Harkness and Roman P. Artymyshyn and Barry B. Wolfe},
  journal={Molecular pharmacology},
  year={1988},
  volume={34 3},
  pages={327-33}
}
Since the reports elucidating the sequence of four subtypes of muscarinic cholinergic receptors appeared, it has been clear that pharmacological approaches to the study of subtypes of these receptors are inadequate to selectively detect one subtype in the presence of the others. One methodology that can provide more selective reagents with which to study these subtypes is immunology. Thus, using the information on the primary sequence of these receptors available in the literature, rabbits were… CONTINUE READING

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