Antibodies to a scrapie prion protein

@article{Bendheim1984AntibodiesTA,
  title={Antibodies to a scrapie prion protein},
  author={Paul E. Bendheim and Ronald A. Barry and Stephen J. DeArmond and Daniel P. Stites and Stanley B Prusiner},
  journal={Nature},
  year={1984},
  volume={310},
  pages={418-421}
}
Scrapie is a slow infection of the nervous system which progresses in the absence of any apparent immune response1–8. The recent development of a large-scale purification protocol for scrapie prion9 made it possible to obtain substantial quantities of electrophoretically purified prion protein (PrP 27–30) and we report here on the successful production of a rabbit antiserum to PrP 27–30. The antiserum reacted with PrP 27–30 and several lower molecular weight proteins as shown by Western blots… CONTINUE READING

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