Antibodies to Plasmodium falciparum Glycosylphosphatidylinositols: Inverse Association with Tolerance of Parasitemia in Papua New Guinean Children and Adults

  title={Antibodies to Plasmodium falciparum Glycosylphosphatidylinositols: Inverse Association with Tolerance of Parasitemia in Papua New Guinean Children and Adults},
  author={C. Boutlis and D. Gowda and R. S. Naik and G. Maguire and C. Mgone and M. Bockarie and M. Lagog and Erwin Ibam and K. Lorry and N. Anstey},
  journal={Infection and Immunity},
  pages={5052 - 5057}
  • C. Boutlis, D. Gowda, +7 authors N. Anstey
  • Published 2002
  • Biology, Medicine
  • Infection and Immunity
  • ABSTRACT Individuals living in regions of intense malaria transmission exhibit natural immunity that facilitates persistence of parasitemia at controlled densities for much of the time without symptoms. This aspect of immunity has been referred to as malarial “tolerance” and is thought to partly involve inhibition of the chain of events initiated by a parasite toxin(s) that may otherwise result in cytokine release and symptoms such as fever. Antibodies to the candidate Plasmodium falciparum… CONTINUE READING
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