Antibodies to Plasmodium falciparum Glycosylphosphatidylinositols: Inverse Association with Tolerance of Parasitemia in Papua New Guinean Children and Adults

@article{Boutlis2002AntibodiesTP,
  title={Antibodies to Plasmodium falciparum Glycosylphosphatidylinositols: Inverse Association with Tolerance of Parasitemia in Papua New Guinean Children and Adults},
  author={Craig Steven Boutlis and D. Channe Gowda and Ramachandra S. Naik and Graeme P Maguire and Charles S. Mgone and Moses Bockarie and Moses Lagog and Erwin Ibam and Kerry Lorry and Nicholas M. Anstey},
  journal={Infection and Immunity},
  year={2002},
  volume={70},
  pages={5052 - 5057}
}
ABSTRACT Individuals living in regions of intense malaria transmission exhibit natural immunity that facilitates persistence of parasitemia at controlled densities for much of the time without symptoms. This aspect of immunity has been referred to as malarial “tolerance” and is thought to partly involve inhibition of the chain of events initiated by a parasite toxin(s) that may otherwise result in cytokine release and symptoms such as fever. Antibodies to the candidate Plasmodium falciparum… 
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Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria.
Differential Antibody Responses to P. falciparum Glycosylphosphatidylinositol Anchors in Patients With Cerebral and Mild Malaria
TLDR
In this study, IgG responses against P. falciparum GPIs and a baculovirus recombinant MSP1p19 antigen evaluated in two distinct groups of 70 patients each, indicating a potential anti -toxin role for anti -GPI antibodies associated with protection against cerebra l malaria.
Antibodies to Plasmodium falciparum Rifin Proteins Are Associated with Rapid Parasite Clearance and Asymptomatic Infections
TLDR
The likelihood that these antibodies could confer a certain degree of protection against malaria is supported by the findings of statistically higher levels of antirifin antibodies to all four rifin proteins in a group of 42 asymptomatic parasitemic children.
Neutralization of Malaria Glycosylphosphatidylinositol In Vitro by Serum IgG from Malaria-Exposed Individuals
TLDR
It is demonstrated that IgG from Plasmodium falciparum-exposed individuals can significantly inhibit the GPI-induced activation of macrophages in vitro, as shown by reduced levels of tumor necrosis factor production and attenuation of CD40 expression.
Immunoglobulin G (IgG) responses to Plasmodium falciparum glycosylphosphatidylinositols are short-lived and predominantly of the IgG3 subclass.
TLDR
This study shows that immunoglobulin G (IgG)-subclass responses elicited by the proposed P. falciparum toxin glycosylphosphatidylinositol (GPI) in Papua New Guinean subjects 5-60 years old predominantly involve IgG(3), with a lesser contribution from IgG1 and an absence of IgG2 and IgG3.
Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination.
TLDR
GPIs are potentially amenable to specific therapeutic inhibition and vaccination; more needs to be known about their dual roles in malaria pathogenesis and protection for these strategies to succeed.
Age-dependent impairment of IgG responses to glycosylphosphatidylinositol with equal exposure to Plasmodium falciparum among Javanese migrants to Papua, Indonesia.
TLDR
Host age, independent of cumulative exposure, apparently represents a key determinant of the quantitative and qualitative nature of the IgG response to P. falciparum GPI.
IgG antibodies to synthetic GPI are biomarkers of immune-status to both Plasmodium falciparum and Plasmodium vivax malaria in young children
TLDR
This study highlights that in young children, IgG to PfGPI might be a useful marker of immune-status to both P. falciparum and P. vivax infections, and potentially useful to help malaria control programs to identify populations at-risk.
Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls.
TLDR
Higher levels of IgM and IgG antibodies to GPI in young children were associated with disease severity and were short-lived, compared with matched healthy controls.
Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
TLDR
The data suggest that the Ab response against P. falciparum GPI is not associated with P. Falconerum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon, but this Ab response could be related to ongoing parasitaemia in the Angolan patients.
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