Antibodies to Molds and Satratoxin in Individuals Exposed in Water-Damaged Buildings

@article{Vojdani2003AntibodiesTM,
  title={Antibodies to Molds and Satratoxin in Individuals Exposed in Water-Damaged Buildings},
  author={Aristo Vojdani and Jack Dwayne Thrasher and Roberta A Madison and Michael R. Gray and Gunnar Heuser and Andrew W. Campbell},
  journal={Archives of Environmental Health: An International Journal},
  year={2003},
  volume={58},
  pages={421 - 432}
}
Immunoglobulin (Ig)A, IgM, and IgG antibodies against Penicillium notatum, Aspergillus niger, Stachybotrys chartarum, and satratoxin H were determined in the blood of 500 healthy blood donor controls, 500 random patients, and 500 patients with known exposure to molds. The patients were referred to the immunological testing laboratory for health reasons other than mold exposure, or for measurement of mold antibody levels. Levels of IgA, IgM, and IgG antibodies against molds were significantly… 
Cross-Reactivity of Aspergillus, Penicillium, and Stachybotrys Antigens Using Affinity-Purified Antibodies and Immunoassay
  • A. Vojdani
  • Biology
    Archives of environmental health
  • 2004
TLDR
The findings of this study demonstrate that cross-reactivity studies between different molds require the use of affinity-purified antibodies and a sensitive and quantitative assay with untreated antigens, which is less widespread than previously believed.
Immune Response among Patients Exposed to Molds
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T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds, suggesting IgE mediated or other non-immune mechanisms could be the cause of their symptoms.
Detection of Trichothecene Mycotoxins in Sera from Individuals Exposed to Stachybotrys chartarum in Indoor Environments
TLDR
Data from this study suggest that trichothecene mycotoxins can be demonstrated in the tissues of certain individuals exposed to S. chartarum in contaminated buildings.
Antibody Response to Long‐term and High‐dose Mould‐exposed Sawmill Workers
TLDR
It is strongly suggested that high mould exposure can induce a strong IgG and IgA response in a dose‐dependent manner.
Mold and mycotoxins: effects on the neurological and immune systems in humans.
Environmental and molecular study of fungal flora in asthmatic patients.
Detection of macrocyclic trichothecene mycotoxin in a caprine (goat) tracheal instillation model
TLDR
Results showed that MTMs are detectable in experimental animals soon after challenge and contribute to the understanding of the role of these mycotoxins in the disease process following mold exposure.
Neural Autoantibodies and Neurophysiologic Abnormalities in Patients Exposed to Molds in Water-Damaged Buildings
TLDR
Exposure to molds in water-damaged buildings increased the risk for development of neural autoantibodies, peripheral neuropathy, and neurophysiologic abnormalities in exposed individuals.
Molds and Mycotoxins in Autopsy Specimens in a Death Related to Fungal Pneumonia and Pancytopenia, Marijuana Usage and a Water-Damaged Home: A Case Report.
TLDR
Because the man was well before moving into the home, then became very ill and eventually expired it is concluded that the home exposure was most likely the principle cause of illness and death.
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