Antibodies to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera.

@article{Ravindranath2010AntibodiesTH,
  title={Antibodies to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera.},
  author={Mepur H Ravindranath and Hugo Kaneku and Nadim El-Awar and Luis Eduardo Morales-Buenrostro and Paul I. Terasaki},
  journal={Journal of immunology},
  year={2010},
  volume={185 3},
  pages={
          1935-48
        }
}
Natural anti-HLA Abs found in sera of healthy nonalloimmunized males recognize HLA-Ia alleles parallel to those recognized by anti-HLA-E mAbs (MEM-E/02/06/07). Therefore, some of the HLA-Ia Abs seen in healthy males could be due to anti-HLA-E Abs cross-reacting with HLA-Ia. If anti-HLA-E Abs occur in healthy nonalloimmunized males, it can be assessed whether they evoke HLA-Ia reactivity as do mouse HLA-E mAbs. IgG and IgM Abs to HLA-E and HLA-Ia alleles are identified in sera of healthy males… CONTINUE READING

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