Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis

@article{Len2006AntibodiesTC,
  title={Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis},
  author={F. Le{\'o}n and N. Contractor and I. Fuss and T. Marth and E. Lahey and Shoko Iwaki and A. la Sala and V. Hoffmann and W. Strober and B. Kelsall},
  journal={The Journal of Immunology},
  year={2006},
  volume={177},
  pages={6974 - 6982}
}
Prior studies indicated the ability of Abs to complement receptor 3 (CR3, CD11b/CD18) to suppress the production of IL-12 from immune cells. Therefore, we tested the ability of an anti-CR3 Ab (clone M1/70) to treat established IL-12-dependent Th1-mediated inflammation in murine models. Systemic administration of anti-CR3 significantly ameliorated established intestinal inflammation following the intrarectal administration of trinitrobenzene sulfonic acid (TNBS-colitis), as well as colitis and… Expand
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