Antibodies to CD40 induce a lethal cytokine cascade after syngeneic bone marrow transplantation.

@article{Hixon2001AntibodiesTC,
  title={Antibodies to CD40 induce a lethal cytokine cascade after syngeneic bone marrow transplantation.},
  author={Julie A. Hixon and Bruce R Blazar and Miriam Anver and Robert H. Wiltrout and William Joseph Murphy},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2001},
  volume={7 3},
  pages={136-43}
}
CD40 stimulation, by either antibody or ligand, has been shown to inhibit the growth of a variety of neoplastic cells, both in vivo and in vitro. In this study, we assessed the effects of CD40 stimulation using a murine agonistic CD40 monoclonal antibody (MoAb) (FGK115) or a soluble recombinant murine CD40 ligand (srmCD40L) in both lethally irradiated and nonirradiated BALB/c mice. Toxicity after CD40 stimulation was not observed in nonirradiated animals receiving up to 100 microg of the… CONTINUE READING
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