Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.

@article{Burgener2008AntibodiesSF,
  title={Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.},
  author={Iwan Anton Burgener and Thomas W. Jungi},
  journal={Veterinary immunology and immunopathology},
  year={2008},
  volume={124 1-2},
  pages={184-91}
}
Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns on microbes, and ligand recognition results in production of pro-inflammatory cytokines, reactive oxygen and nitrogen intermediates, and upregulation of costimmulatory molecules. The purpose of this study was to test antibodies specific for human or murine TLR2, 3, 4, 5 and 9 for their use in dogs. Twenty-two antibodies were assessed for recognition of canine monocytes (Mo), granulocytes (Gr) or lymphocytes (Ly) by flow… CONTINUE READING

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