Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis

@article{Cid2004AntibodiesRT,
  title={Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis},
  author={Cristina Cid and Jos{\'e} C. {\'A}lvarez-cerme{\~n}o and Emilio Camafeita and Matilde Salinas and Alberto Alc{\'a}zar},
  journal={The FASEB Journal},
  year={2004},
  volume={18}
}
Oligodendrocyte precursor cells (OPCs) are extremely efficient at remyelination. These cells persist in the adult human central nervous system and can proliferate. However, the failure to remyelinate is a pathological characteristic of the human demyelinating disease multiple sclerosis (MS), which suggests that these cells are ineffective in this disorder. This paper reports that IgG antibodies in the cerebrospinal fluid (CSF) of MS patients specifically recognize an antigen on OPCs in culture… 
Anti‐heat shock protein 90β antibodies decrease pre‐oligodendrocyte population in perinatal and adult cell cultures. Implications for remyelination in multiple sclerosis
TLDR
These findings demonstrate, for the first time in vitro, a feasible mechanism to decrease the production of new oligodendrocytes, thus limiting the possibility of remyelination in multiple sclerosis.
Anti-heat shock protein 90β antibodies are detected in patients with multiple sclerosis during remission
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TLDR
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TLDR
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High cytotoxic sensitivity of the oligodendrocyte precursor cells to HSP90 inhibitors in cell cultures
Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells
TLDR
The first evidence of cell-surface Hsp90 expression in a cancer cell line from nervous tissue is described and may indicate a novel target for anti-tumoral agents.
Positive or Negative Involvement of Heat Shock Proteins in Multiple Sclerosis Pathogenesis: An Overview
TLDR
This article reviews the current understanding of the involvement of the principal HSP families in MS and examines protective effects of HSPs in a variety of brain disease models.
Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues.
TLDR
In addition to identifying an antibody reagent that identifies a highly conserved epitope expressed by MSCs from different species, this study points to a potential role for Hsp90beta in MSC biology.
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    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
It is suggested that the susceptibility of oligodendrocytes and adult O/2A progenitor cells to complement-induced lysis, combined with other specific properties of adult O-2a progenitors, are consistent with--and may be a contributing factor--both in the generation of demyelinating lesions in multiple sclerosis and also in the failure of these lesions to be successfully repaired in adult multiple sclerosis patients.
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