Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment.

@article{Zibert1995AntibodiesIH,
  title={Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment.},
  author={Alenka Zibert and Eckart Schreier and Michael Roggendorf},
  journal={Virology},
  year={1995},
  volume={208 2},
  pages={653-61}
}
It has been postulated that antibodies specific to the hypervariable region 1 (HVR1) within the putative envelop protein E2 of hepatitis C virus (HCV) can neutralize virus. We studied such antibodies in sera of patients who were infected in a single-source outbreak by a contaminated anti-D immunoglobulin preparation (HCV-AD78). The nucleotide sequences of cDNAs encoding HVR1 of HCV-AD78 were determined. The four major variants (HVR1.A, B, C, and D) were expressed as fusion proteins in… CONTINUE READING

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