Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.

@article{OConnor2005AntibodiesFI,
  title={Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.},
  author={Kevin C. O'Connor and Heiner Appel and Lisa Bregoli and Matthew E Call and Ingrid Catz and Jennifer A W Chan and Nicole H. Moore and Kenneth G. Warren and Susan J. Wong and David A. Hafler and Kai W Wucherpfennig},
  journal={Journal of immunology},
  year={2005},
  volume={175 3},
  pages={1974-82}
}
Autoantibodies to myelin oligodendrocyte glycoprotein (MOG) can induce demyelination and oligodendrocyte loss in models of multiple sclerosis (MS). Whether anti-MOG Abs play a similar role in patients with MS or inflammatory CNS diseases by epitope spreading is unclear. We have therefore examined whether autoantibodies that bind properly folded MOG protein are present in the CNS parenchyma of MS patients. IgG was purified from CNS tissue of 14 postmortem cases of MS and 8 control cases… CONTINUE READING