Antibodies directed against the MHC-I molecule H-2Dd complexed with an antigenic peptide: similarities to a T cell receptor with the same specificity.

@article{Polakova2000AntibodiesDA,
  title={Antibodies directed against the MHC-I molecule H-2Dd complexed with an antigenic peptide: similarities to a T cell receptor with the same specificity.},
  author={Katarina Polakova and Daniel Plaksin and Doo Hyun Chung and Igor M. Belyakov and Jay A. Berzofsky and David H Margulies},
  journal={Journal of immunology},
  year={2000},
  volume={165 10},
  pages={5703-12}
}
alphabeta TCRs, which use an Ab-like structure to form a combining site, recognize molecular complexes consisting of peptides bound to MHC class I (MHC-I) or class II (MHC-II) molecules. To explore the similarities and differences between Ab and T cell recognition of similar structures, we have isolated two mAbs, KP14 and KP15, that specifically bind H-2D(d) complexed with an HIV envelope gp160-derived peptide, P18-I10. These Abs are MHC and peptide specific. Fine specificity of mAb binding was… CONTINUE READING