Antibodies as pharmacologic tools for studies on the regulation of energy balance.

@article{Hofbauer2008AntibodiesAP,
  title={Antibodies as pharmacologic tools for studies on the regulation of energy balance.},
  author={Karl G. Hofbauer and Anne-Catherine Lecourt and J. Peter},
  journal={Nutrition},
  year={2008},
  volume={24 9},
  pages={791-7}
}
OBJECTIVE Active immunization in rats may serve several purposes: the production of a disease-like phenotype, the generation of pharmacologic tools, and the development of clinically useful therapies. We selected the melanocortin-4 receptor (MC4R) as a target because its blockade could provide a treatment for anorexia and cachexia. METHODS We used a sequence of the N-terminal (NT) domain of the MC4R as an antigen. Rats immunized against the NT peptide produced specific MC4R antibodies (Abs… CONTINUE READING
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