Antibodies and neuronal autoimmune disorders of the CNS

@article{Graus2009AntibodiesAN,
  title={Antibodies and neuronal autoimmune disorders of the CNS},
  author={Francesc Graus and Albert Saiz and Josep Dalmau},
  journal={Journal of Neurology},
  year={2009},
  volume={257},
  pages={509-517}
}
We review the neuronal antibodies described in CNS disorders in order to clarify their diagnostic value, emphasize potentials pitfalls and limitations in the diagnosis of paraneoplastic neurological syndromes (PNS), and examine the current evidence for a possible pathogenic role. We propose to classify the neuronal antibodies associated with syndromes resulting from CNS neuronal dysfunction into two groups according to the location of the antigen: inside the neuron or in the cell membrane… 
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342 Citations
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342 Citations

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Antibody testing in peripheral nerve disorders.

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An overview of neuron-directed autoimmunity as a novel class of inflammatory CNS disorders, their differential diagnoses, clinical hallmarks, imaging features, characteristic laboratory, electrophysiological, cerebrospinal fluid and neuropathological findings, cellular and molecular disease mechanisms, as well as therapeutic options are provided.

Autoimmune Epilepsies

Emerging findings in patients with immune-associated disorders of the gray central nervous system matter make it plausible that immunological therapies, preferably early after characterization of the antibodies, offer opportunities to restore the health of affected patients.

New concepts in paraneoplastic neurological syndromes.

Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system

This work provides an overview of entities, clinical hallmarks, imaging features, characteristic laboratory, electrophysiological, cerebrospinal fluid and neuropathological findings, cellular and molecular disease mechanisms as well as therapeutic options in these two broad categories of inflammatory CNS disorders.

Antineuronal autoantibodies in neurological disorders

  • K. Bürk
  • Biology, Medicine
    Biomolecular concepts
  • 2011
The review gives an overview of the common characteristics of each group and provides more detailed information on single abs and the associated clinical syndromes.
...

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