Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism

@article{GonzalezGronow2010AntibodiesAT,
  title={Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism},
  author={Mario Gonzalez-Gronow and Miguel T Cuchacovich and Rina Francos and Stephanie Cuchacovich and Salvatore Vincent Pizzo},
  journal={Journal of Neuroimmunology},
  year={2010},
  volume={227},
  pages={153-161}
}
Autistic children show elevated serum levels of autoantibodies to several proteins essential for the function of normal brains. The voltage-dependent anion channel (VDAC) and hexokinase-I, a VDAC protective ligand, were identified as targets of this autoimmunity in autistic children. These autoantibodies were purified using immunoaffinity chromatographic techniques. Both antibodies induce apoptosis of cultured human neuroblastoma cells. Because VDAC and hexokinase-I are essential for brain… CONTINUE READING

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