Antibodies against the donor antigen glutathione S-transferase T1 after renal transplantation.

@article{Aguilera2005AntibodiesAT,
  title={Antibodies against the donor antigen glutathione S-transferase T1 after renal transplantation.},
  author={Isabel Aguilera and Ingeborg Wichmann and Miguel Angel Gentil and Francisca Gonz{\'a}l{\'e}z-Escribano and Antonio N{\'u}{\~n}ez-Rold{\'a}n},
  journal={Transplantation proceedings},
  year={2005},
  volume={37 3},
  pages={1457-8}
}
The aim of the present study was to determine whether a kidney graft expressing the glutathione S-transferase T1 enzyme (GSTT1) could cause an alloimmune response in a recipient with the null GSTT1 genotype that was similar to that observed in liver transplant. We have found anti-GSTT1 antibodies in the sera of a number of patients and confirmed that only one of the four possible genetic combinations--positive donor/null receptor--could lead to the production of these antibodies. Nevertheless… CONTINUE READING