Antibodies against native type II collagen do not precede the clinical onset of rheumatoid arthritis.

@article{Mttnen1988AntibodiesAN,
  title={Antibodies against native type II collagen do not precede the clinical onset of rheumatoid arthritis.},
  author={Timo M{\"o}tt{\"o}nen and Pekka J Hannonen and Masanori Oka and Jaakko Rautiainen and I Jokinen and Heikki S. Arvilommi and Timo Palosuo and Kimmo Aho},
  journal={Arthritis and rheumatism},
  year={1988},
  volume={31 6},
  pages={776-9}
}
Serum levels of IgG and IgM antibodies to native human type II collagen were determined in 22 pre-illness sera from subjects who developed seropositive rheumatoid arthritis (RA) 4 months to 5 years after sera were obtained, in 51 specimens from 35 healthy controls, and in 4-5 specimens from 58 patients with recent-onset RA. The antibody levels in all pre-illness serum specimens fell within the range seen for the healthy controls. Four RA patients had an IgG class antibody level and 4 had an IgM… CONTINUE READING

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