Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis.

@article{Mori2012AntibodiesAM,
  title={Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis.},
  author={Shuuichi Mori and Sachiho Kubo and Takuyu Akiyoshi and Shigeru Yamada and Tsuyoshi Miyazaki and Harumi Hotta and Junzo Desaki and Masahiko Kishi and Tetsuro Konishi and Yuri Nishino and Atsuo Miyazawa and Naoki Maruyama and Kazuhiro Shigemoto},
  journal={The American journal of pathology},
  year={2012},
  volume={180 2},
  pages={798-810}
}
Antibodies against acetylcholine receptors (AChRs) cause pathogenicity in myasthenia gravis (MG) patients through complement pathway-mediated destruction of postsynaptic membranes at neuromuscular junctions (NMJs). However, antibodies against muscle-specific kinase (MuSK), which constitute a major subclass of antibodies found in MG patients, do not activate the complement pathway. To investigate the pathophysiology of MuSK-MG and establish an experimental autoimmune MG (EAMG) model, we injected… CONTINUE READING

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