Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology.

@article{Lykhmus2011AntibodiesAE,
  title={Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology.},
  author={Olena Lykhmus and Lyudmyla Koval and Maryna V. Skok and Marios Zouridakis and Paraskevi Zisimopoulou and Socrates J Tzartos and V. I. Tsetlin and Sylvie Granon and Jean-Pierre Changeux and Sergiy V. Komisarenko and Isabelle Clo{\"e}z-Tayarani},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={24 4},
  pages={
          693-704
        }
}
Nicotinic acetylcholine receptors (nAChRs) of α4β2 and α7 subtypes expressed in the brain neurons are involved in regulating memory and cognition. Their level is decreased upon several neurodegenerative disorders including Alzheimer's disease (AD), although the reasons for such a decrease are not completely understood. To test whether the nAChR-specific antibodies can affect the brain nAChRs and influence the behavior, we either immunized mice with recombinant extracellular domains of α4 and α7… CONTINUE READING

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The presence and origin of autoantibodies against 4 and 7 nicotinic acetylcholine receptors in the human blood: possible relevance to alzheimer pathology

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  • J Alzheimers Dis (submitted)
  • 2011
1 Excerpt

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