Antibodies against cysteine string proteins inhibit evoked neurotransmitter release at Xenopus neuromuscular junctions.

@article{Poage1999AntibodiesAC,
  title={Antibodies against cysteine string proteins inhibit evoked neurotransmitter release at Xenopus neuromuscular junctions.},
  author={Robert E. Poage and Stephen D Meriney and Cameron B. Gundersen and Joy A. Umbach},
  journal={Journal of neurophysiology},
  year={1999},
  volume={82 1},
  pages={
          50-9
        }
}
Cysteine string proteins (CSPs) are evolutionarily conserved proteins that are associated with synaptic vesicles and other regulated secretory organelles. To investigate the role of CSPs in vertebrate neuromuscular transmission, we introduced anti-CSP antibodies into the cell bodies of Xenopus spinal motor neurons that form synapses with embryonic muscle cells in culture. These antibodies produced a rapid (within 3-6 min), and in most cases complete, inhibition of stimulus-dependent… CONTINUE READING

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