Antibodies against astrocyte M1 and M2 muscarinic cholinoceptor from schizophrenic patients' sera.

@article{Borda2004AntibodiesAA,
  title={Antibodies against astrocyte M1 and M2 muscarinic cholinoceptor from schizophrenic patients' sera.},
  author={Tania G. Borda and Ricardo Mart{\'i}n G{\'o}mez and Mar{\'i}a Isabel Berr{\'i}a and Leonor Sterin-Borda},
  journal={Glia},
  year={2004},
  volume={45 2},
  pages={144-54}
}
We demonstrated the presence of circulating antibodies from schizophrenic patients able to interact with cultured astrocytes activating muscarinic acetylcholine receptors (mAChRs). Sera and purified IgG from 15 paranoid schizophrenic and 15 age-matched normal subjects were studied by indirect immunofluorescence (IFI), flow cytometry, dot blot, enzyme immunoassay (ELISA), and radioligand competition assays. Astrocyte membranes and/or a synthetic peptide, with identical amino acid sequence of… CONTINUE READING