Antibiotics in early life alter the murine colonic microbiome and adiposity

@article{Cho2012AntibioticsIE,
  title={Antibiotics in early life alter the murine colonic microbiome and adiposity},
  author={Ilseung Cho and Shingo Yamanishi and Laura M. Cox and Barbara A. Meth{\'e} and Jiri Zavadil and Kelvin Li and Zhan Gao and Douglas Mahana and Kartik Raju and Isabel Teitler and Huilin Li and Alexander V. Alekseyenko and Martin J. Blaser},
  journal={Nature},
  year={2012},
  volume={488},
  pages={621-626}
}
Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic… CONTINUE READING
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