Antibiotics in early life alter the murine colonic microbiome and adiposity

  title={Antibiotics in early life alter the murine colonic microbiome and adiposity},
  author={Ilseung Cho and Shingo Yamanishi and Laura M. Cox and Barbara A. Meth{\'e} and Jiri Zavadil and Kelvin Li and Zhan Gao and Douglas Mahana and Kartik Raju and Isabel Teitler and Huilin Li and Alexander V. Alekseyenko and Martin J. Blaser},
Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 430 extracted citations


Publications referenced by this paper.
Showing 1-10 of 67 references

at the interface of health and disease

  • I. Cho, Blaser, M. J. The human microbiome
  • Nature Rev. Genet. 13, 260–270
  • 2012

effects on gut mucosa and epithelial gene expression

  • Reikvam, D. H. et al. Depletion of murine intestinal microbiota
  • PLoS ONE 6, e17996
  • 2011

Similar Papers

Loading similar papers…