Antibiotics enhance binding by human lipid A-reactive monoclonal antibody HA-1A to smooth gram-negative bacteria.

@article{Siegel1993AntibioticsEB,
  title={Antibiotics enhance binding by human lipid A-reactive monoclonal antibody HA-1A to smooth gram-negative bacteria.},
  author={Scott A. Siegel and Martin E Evans and Matthew Pollack and Andrea O. Leone and Cheryl Ann S. Kinney and Susan H Tam and Peter E. Daddona},
  journal={Infection and immunity},
  year={1993},
  volume={61 2},
  pages={
          512-9
        }
}
The effect of antibiotic exposure of phenotypically smooth gram-negative bacteria on binding by the human lipid A-reactive monoclonal antibody HA-1A (trademark of Centocor, Inc.) was examined by liquid-phase immunoassay and by dual-parameter flow cytometry (fluorescence-activated cell sorter [FACS]) analysis. HA-1A exhibited dose-dependent binding to untreated rough gram-negative bacteria such as the Escherichia coli D21F2 Re chemotype strain but little binding to untreated smooth strains such… CONTINUE READING

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