Antibiotics as intermicrobial signaling agents instead of weapons.

  title={Antibiotics as intermicrobial signaling agents instead of weapons.},
  author={Juan Francisco Linares and Ingrid Gustafsson and Fernando Baquero and Jos{\'e} L Mart{\'i}nez},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 51},
It has been widely assumed that the ecological function of antibiotics in nature is fighting against competitors. This made them a good example of the Darwinian struggle-for-life in the microbial world. Based on this idea, it also has been believed that antibiotics, even at subinhibitory concentrations, reduce virulence of bacterial pathogens. Herein, using a combination of genomic and functional assays, we demonstrate that specific antibiotics (namely tobramycin, tetracycline, and norfloxacin… CONTINUE READING
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