Antibiotics: An irresistible newcomer

  title={Antibiotics: An irresistible newcomer},
  author={Gerard D. Wright},
A screen of 10,000 bacterial strains, cultured in their normal soil, has uncovered an antibiotic with broad and potent activity. And because the compound targets lipid molecules, developing resistance is probably difficult. See Article p.455 
Texiobactin, a Potent Killer of Antibiotic Resistant Pathogens
Antibiotic resistance is a major global concern that primarily affects public health. Texiobactin is a newly discovered antibiotic produces by soil microbes isolated from natural environment. Drug is
Chemistry and Biology of Teixobactin.
This review summarizes recent progresses in the understanding of many aspects of teixobactin, including chemical structure, biological activity, biosynthetic pathway, and mode of action, and the structure-activity relationship (SAR) studies.
Teixobactin: a novel anti-infective agent
  • M. McCarthy
  • Biology
    Expert review of anti-infective therapy
  • 2019
The discovery and development of teixobactin and its analogs are reviewed to explore how they may serve as an example for other novel compounds that are in development to address the expanding problem of antimicrobial drug resistance.
Teixobactin: a novel antibiotic in treatment of gram positive bacterial infections.
  • A. Kali
  • Biology
    Journal of clinical and diagnostic research : JCDR
  • 2015
The isolation of teixobactin from soil using iChip not only marks the development of a new antibiotic class with low risk of acquiring resistance, but also opens up infinite possibilities to discover useful molecules from unexplored strata of microbial kingdom.
New Found Hope for Antibiotic Discovery: Lipid II Inhibitors.
A summary of the role of lipid II as well as an overview and insight into the structural features of macrocyclic peptides that inhibit this bacterial cell wall component are provided.
Teixobactin: A Powerful Tool for Combating Resistant Strains
Its chemistry, mode of action, in vitro and in vivo aspects have been thrown light upon and its effect in mice models has given a hope for overpowering resistance.
The “Three Cs” of Novel Antibiotic Discovery and Production through Synthetic Biology: Biosynthetic Gene Clusters, Heterologous Chassis, and Synthetic Microbial Consortia
This review discusses recent advances in the use of synthetic biology methodologies to discover and produce novel antimicrobials; in particular, the work being carried out on biosynthetic gene clusters, heterologous chassis, and synthetic microbial consortia, the “three Cs” of the title.
The algal chloroplast as a platform for synthesis of lytic enzymes targeting Gram-negative pathogens
This work demonstrates that the eukaryotic microalgae Chlamydomonas reinhardtii can be modified to produce endolysins that target Gram-negative bacteria, offering a new photosynthetic platform with limitless potential for sustainable production.
Recent progress on the development of antibiotics from the genus Micromonospora
It may be possible to revive formerly used antibiotics produced by Micromonospora and study of this genus may facilitate discovery of novel bioactive molecules.


Drugs for bad bugs: confronting the challenges of antibacterial discovery
The experience of evaluating more than 300 genes and 70 high-throughput screening campaigns over a period of 7 years is shared, and what is learned is looked at and how that has influenced GlaxoSmithKline's antibacterials strategy going forward.
Platforms for antibiotic discovery
  • K. Lewis
  • Biology
    Nature Reviews Drug Discovery
  • 2013
Strategies to re-establish viable platforms for antibiotic discovery include investigating untapped natural product sources such as uncultured bacteria, establishing rules of compound penetration to enable the development of synthetic antibiotics, developing species-specific antibiotics and identifying prodrugs that have the potential to eradicate dormant persisters, which are often responsible for hard-to-treat infections.
Challenges of Antibacterial Discovery
  • L. Silver
  • Biology
    Clinical Microbiology Reviews
  • 2011
The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output of the effort.
Something old, something new: revisiting natural products in antibiotic drug discovery.
Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products, and natural products are poised for a renaissance to address what is a pressing health care crisis.
Glycopeptide Antibiotic Resistance Genes in Glycopeptide-Producing Organisms
Results suggest that glycopeptide-producing organisms may have been the source of resistance genes in vancomycin-resistant enterococci.
Insights into the phylogeny and coding potential of microbial dark matter
This study applies single-cell genomics to target and sequence 201 archaeal and bacterial cells from nine diverse habitats belonging to 29 major mostly uncharted branches of the tree of life and provides a systematic step towards a better understanding of biological evolution on the authors' planet.
Use of Ichip for High-Throughput In Situ Cultivation of “Uncultivable” Microbial Species
It is shown that microbial recovery in the ichip exceeds manyfold that afforded by standard cultivation, and the grown species are of significant phylogenetic novelty.
Is the GAIN Act a turning point in new antibiotic discovery?
  • E. Brown
  • Biology
    Canadian journal of microbiology
  • 2013
The lessons of failure are examined as are the prospects for a renewed effort in antibiotic drug discovery and development stimulated by new investments in both the public and private sector.
Prioritized Current Unmet Needs for Antibacterial Therapies
The goal here is to describe and prioritize the current areas of greatest unmet need for new antibacterial development based on an understanding of the most serious treatment challenges facing patients and their providers today.
A new antibiotic kills pathogens without detectable resistance
The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.