Antibiotic therapy in preterm premature rupture of membranes: a randomized, prospective, double-blind trial.

@article{Johnston1990AntibioticTI,
  title={Antibiotic therapy in preterm premature rupture of membranes: a randomized, prospective, double-blind trial.},
  author={Matthew M. W. Johnston and Luis S{\'a}nchez-Ramos and Arthur J Vaughn and M W Todd and Guy I Benrubi},
  journal={American journal of obstetrics and gynecology},
  year={1990},
  volume={163 3},
  pages={743-7}
}
The use of antibiotics in the management of preterm, premature rupture of membranes remains controversial. By use of a prospective randomized double-blind design we investigated the maternal-fetal benefits associated with antibiotic therapy in 85 women with premature rupture of membranes at 34 weeks' estimated gestational age. In the treatment group 40 patients received intravenous mezlocillin for 48 hours followed by oral ampicillin until delivery. In the control group 45 patients received… CONTINUE READING