Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

@article{Mercer1997AntibioticTF,
  title={Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.},
  author={Brian M. Mercer and Menachem Miodovnik and Gary R Thurnau and Robert L Goldenberg and Anita F Das and R. Douglas Ramsey and Yolanda A Rabello and Paul J. Meis and Atef H. Moawad and Jay D. Iams and J Peter van Dorsten and Richard H. Paul and Steve Bottoms and Gerald C Merenstein and Elizabeth A Thom and James M Roberts and Donald R. McNellis},
  journal={JAMA},
  year={1997},
  volume={278 12},
  pages={989-95}
}
CONTEXT Intrauterine infection is thought to be one cause of preterm premature rupture of the membranes (PPROM). Antibiotic therapy has been shown to prolong pregnancy, but the effect on infant morbidity has been inconsistent. OBJECTIVE To determine if antibiotic treatment during expectant management of PPROM will reduce infant morbidity. DESIGN Randomized, double-blind, placebo-controlled trial. SETTING University hospitals of the National Institute of Child Health and Human Development… CONTINUE READING