Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich

@inproceedings{Bchler2014AntibioticSO,
  title={Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich},
  author={Andrea C B{\"u}chler and Silvana K. Rampini and Simon Stelling and Bruno Ledergerber and Silke Peter and Alexander Schweiger and Christian Ruef and Reinhard Zbinden and Roberto F Speck},
  booktitle={BMC infectious diseases},
  year={2014}
}
BACKGROUND Clostridium difficile infection (CDI) remains a major health problem worldwide. Antibiotic use, in general, and clindamycin and ciprofloxacin, in particular, have been implicated in the pathogenesis of CDI. Here, we hypothesized that antibiotics that are highly active in vitro against C. difficile are less frequently associated with CDI than others. The primary goals of our study were to determine if antibiotic susceptibility and CDI are associated and whether the antimicrobial… CONTINUE READING
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