Antibiotic-resistant bugs in the 21st century--a clinical super-challenge.

  title={Antibiotic-resistant bugs in the 21st century--a clinical super-challenge.},
  author={Cesar Andres Diaz Arias and Barbara E. Murray},
  journal={The New England journal of medicine},
  volume={360 5},
  • C. AriasB. Murray
  • Published 10 December 2009
  • Medicine
  • The New England journal of medicine
Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet. 

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This review focuses on antibiotic resistance mechanisms of Enterococcus and Campylobacter, and new antibacterial agents against Enterococcin and Campolobacter through de novo or semi- synthesis in the period from 2003 until mid- 2013.


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Introduction to antibiotic resistance.

The absolute number of new antibiotics licensed has declined especially for Gram-negative multidrug-resistant pathogens, and the reasons for this failure are presented here: market issues, big pharma changes, regulatory constraints, difficulties in finding drugable targets and suitable compounds worthy of full development.

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Varenicline-induced manic episode ina patient with bipolar disorder, and effect of maintenance therapy with varenic line on smoking cessation, and effectiveness and safety of thenovel selective nicotinic acetylcholine receptor partial agonist, for smoking cessation.

Extended - spec - 5 . trum β - lactamase - producing Enterobacteriaceae : an emerging public - health concern

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