Antibiotic resistance of bacteria in biofilms

  title={Antibiotic resistance of bacteria in biofilms},
  author={P. Stewart and J. Costerton},
  journal={The Lancet},
  • P. Stewart, J. Costerton
  • Published 2001
  • Biology, Medicine
  • The Lancet
  • Bacteria that adhere to implanted medical devices or damaged tissue can encase themselves in a hydrated matrix of polysaccharide and protein, and form a slimy layer known as a biofilm. Antibiotic resistance of bacteria in the biofilm mode of growth contributes to the chronicity of infections such as those associated with implanted medical devices. The mechanisms of resistance in biofilms are different from the now familiar plasmids, transposons, and mutations that confer innate resistance to… CONTINUE READING
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