Antibiotic resistance of bacteria in biofilms

@article{Stewart2001AntibioticRO,
  title={Antibiotic resistance of bacteria in biofilms},
  author={P. Stewart and J. Costerton},
  journal={The Lancet},
  year={2001},
  volume={358},
  pages={135-138}
}
  • P. Stewart, J. Costerton
  • Published 2001
  • Biology, Medicine
  • The Lancet
  • Bacteria that adhere to implanted medical devices or damaged tissue can encase themselves in a hydrated matrix of polysaccharide and protein, and form a slimy layer known as a biofilm. Antibiotic resistance of bacteria in the biofilm mode of growth contributes to the chronicity of infections such as those associated with implanted medical devices. The mechanisms of resistance in biofilms are different from the now familiar plasmids, transposons, and mutations that confer innate resistance to… CONTINUE READING
    3,435 Citations

    Figures and Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    There is controversy regarding the utility of antiseptics in wound management for diabetic foot ulcer syndrome. The aim of this study is to assess chlorhexidine gluconate at 0.125% vs… Expand
    ConditionsDiabetic Foot
    InterventionDrug
    Mechanisms of antibiotic resistance in bacterial biofilms.
    • P. Stewart
    • Biology, Medicine
    • International journal of medical microbiology : IJMM
    • 2002
    • 949
    Biofilms: Microbial Shelters Against Antibiotics.
    • 46
    Bacterial Biofilms : A Confrontation to Medical Science
    • 1
    • PDF
    Bacterial resistance in biofilm-associated bacteria.
    • 58
    Biofilm-specific antibiotic resistance.
    • 178
    • PDF
    Antibiotics versus biofilm: an emerging battleground in microbial communities
    • 91
    Mechanism of Antimicrobial Resistance in Bacterial Biofilms
    Bacterial Biofilms: Survival Mechanisms and Antibiotic Resistance
    • 21
    • PDF

    References

    SHOWING 1-10 OF 46 REFERENCES
    Mechanisms of biofilm resistance to antimicrobial agents.
    • 3,019
    Biofilm formation as microbial development.
    • 2,810
    Interaction of biofilm bacteria with antibiotics in a novel in vitro chemostat system.
    • 160
    • PDF
    The glycocalyx, biofilm, microbes, and resistant infection.
    • 65
    Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin.
    • 138
    • PDF
    A Dose-Response Study of Antibiotic Resistance inPseudomonas aeruginosa Biofilms
    • 396
    • PDF