Antibiotic resistance is ancient

@article{DCosta2011AntibioticRI,
  title={Antibiotic resistance is ancient},
  author={Vanessa M D'Costa and Christine E. King and Lindsay R. Kalan and Mariya Morar and Wilson W. L. Sung and Carsten Schwarz and Duane G. Froese and Grant Zazula and Fabrice Calmels and R{\'e}gis Debruyne and Geoffrey Brian Golding and Hendrik N. Poinar and Gerard D. Wright},
  journal={Nature},
  year={2011},
  volume={477},
  pages={457-461}
}
The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all cases by the emergence of resistant microbes. This history has been interpreted to mean that antibiotic resistance in pathogenic bacteria is a modern phenomenon; this view is reinforced by the fact that collections of microbes that predate the antibiotic era are highly susceptible to antibiotics. Here we… 

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