Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.

@article{Mandsberg2009AntibioticRI,
  title={Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.},
  author={Lotte Frigaard Mandsberg and Oana Ciofu and Nikolai S Kirkby and Lasse Engbo Christiansen and Henrik Enghusen Poulsen and Niels H\oiby},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 6},
  pages={2483-91}
}
The chronic Pseudomonas aeruginosa infection of the lungs of cystic fibrosis (CF) patients is characterized by the biofilm mode of growth and chronic inflammation dominated by polymorphonuclear leukocytes (PMNs). A high percentage of P. aeruginosa strains show high frequencies of mutations (hypermutators [HP]). P. aeruginosa is exposed to oxygen radicals, both those generated by its own metabolism and especially those released by a large number of PMNs in response to the chronic CF lung… CONTINUE READING