Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide

@inproceedings{Steere2006AntibioticrefractoryLA,
  title={Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide     },
  author={Allen C. Steere and William J. Klitz and Elise E. Drouin and Ben A. Falk and William W Kwok and Gerald T Nepom and Lee Ann Baxter-Lowe},
  booktitle={The Journal of experimental medicine},
  year={2006}
}
An association has previously been shown between antibiotic-refractory Lyme arthritis, the human histocompatibility leukocyte antigen (HLA)-DR4 molecule, and T cell recognition of an epitope of Borrelia burgdorferi outer-surface protein A (OspA163-175). We studied the frequencies of HLA-DRB1-DQA1-DQB1 haplotypes in 121 patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis and correlated these frequencies with in vitro binding of the OspA163-175 peptide to 14 DRB molecules… CONTINUE READING
65 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Molecular characterization of the OspA161-175 T cell epitope associated with treatment-resistant on July 9, 2017 em .rupss.org D ow nladed fom JEM

  • E. E. Drouin, L. J. Glickstein, A. C. Steere
  • VOL. 203, April
  • 2004

Similar Papers

Loading similar papers…