Antibiotic prophylaxis in orthopedic prosthetic surgery.

  title={Antibiotic prophylaxis in orthopedic prosthetic surgery.},
  author={Fausto de Lalla},
  journal={Journal of chemotherapy},
  volume={13 Spec No 1 1},
Staphylococci account for approximately 70% of postoperative infections in orthopedic prosthetic surgery, with the leading organism being Staphylococcus epidermidis. Therefore, the antibiotics most widely used for prophylaxis are cefazolin, cefamandole and cefuroxime, by virtue of their excellent activity against these pathogens. However, methicillin-resistant coagulase-positive and -negative staphylococci are increasingly being reported as the causative agents of postoperative infection in… CONTINUE READING