Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

  title={Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice},
  author={Alexandra E Livanos and Thomas U. Greiner and Pajau Vangay and Wimal W Pathmasiri and Delisha A Stewart and S Mcritchie and Huilin Li and Jennifer C-Y Chung and Jiho Sohn and Sara Kim and Zhan Gao and Cecily M. Barber and Joanne Kim and Sandy Ng and Arlin B. Rogers and Susan Jenkins Sumner and Xue-Song Zhang and Ken Cadwell and Dan Knights and Alexander V. Alekseyenko and Fredrik B{\"a}ckhed and Martin J. Blaser},
  journal={Nature Microbiology},
The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 35 extracted citations


Publications referenced by this paper.
Showing 1-10 of 94 references

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

  • Kostic, D A.
  • Cell Host Microbe 17,
  • 2015

The microbiome of the uncontacted Amerindians

  • Clemente, C J.
  • Sci. Adv. 1,
  • 2015

Similar Papers

Loading similar papers…