Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

@article{Livanos2016AntibioticmediatedGM,
  title={Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice},
  author={Alexandra E Livanos and Thomas U. Greiner and Pajau Vangay and Wimal W Pathmasiri and Delisha A Stewart and S Mcritchie and Huilin Li and Jennifer C-Y Chung and Jiho Sohn and Sara Kim and Zhan Gao and Cecily M. Barber and Joanne Kim and Sandy Ng and Arlin B. Rogers and Susan Jenkins Sumner and Xue-Song Zhang and Ken Cadwell and Dan Knights and Alexander V. Alekseyenko and Fredrik B{\"a}ckhed and Martin J. Blaser},
  journal={Nature Microbiology},
  year={2016},
  volume={1}
}
The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life… CONTINUE READING

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