Antibiotic-mediated antagonism leads to a bacterial game of rock–paper–scissors in vivo

@article{Kirkup2004AntibioticmediatedAL,
  title={Antibiotic-mediated antagonism leads to a bacterial game of rock–paper–scissors in vivo},
  author={Benjamin Kirkup and Margaret Riley},
  journal={Nature},
  year={2004},
  volume={428},
  pages={412-414}
}
Colicins are narrow-spectrum antibiotics produced by and active against Escherichia coli and its close relatives. Colicin-producing strains cannot coexist with sensitive or resistant strains in a well-mixed culture, yet all three phenotypes are recovered in natural populations. Recent in vitro results conclude that strain diversity can be promoted by colicin production in a spatially structured, non-transitive interaction, as in the classic non-transitive model rock–paper–scissors (RPS). In the… 
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TLDR
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