Antibiotic-loaded plaster of Paris implants coated with poly lactide-co-glycolide as a controlled release delivery system for the treatment of bone infections

@article{Benoit1997AntibioticloadedPO,
  title={Antibiotic-loaded plaster of Paris implants coated with poly lactide-co-glycolide as a controlled release delivery system for the treatment of bone infections},
  author={M. A. Benoit and B. Mousset and Ch. Delloye and R. Bouillet and Joel Gillard},
  journal={International Orthopaedics},
  year={1997},
  volume={21},
  pages={403-408}
}
m) of PLA45GA10. This delivery system was implanted into the femoral condyle of rabbits. It was shown that the in vivo release was also closely regulated by the coating depth. In all bone tissues (bone marrow and cortical bone) surrounding the pellets, the drug concentration exceeded the Minimum Inhibitory Concentration for the common causative organisms of bone infections (Staphylococcus aureus) for at least four weeks without inducing serum toxic levels. Due to its cheapness, facility of use… CONTINUE READING