Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.

@article{Mascher2004AntibioticinduciblePR,
  title={Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.},
  author={Thorsten Mascher and Sara L Zimmer and T Smith and John D. Helmann},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 8},
  pages={2888-96}
}
Soil bacteria are among the most prodigious producers of antibiotics. The Bacillus subtilis LiaRS (formerly YvqCE) two-component system is one of several antibiotic-sensing systems that coordinate the genetic response to cell wall-active antibiotics. Upon the addition of vancomycin or bacitracin, LiaRS autoregulates the liaIHGFSR operon. We have characterized the promoter of the lia operon and defined the cis-acting sequences necessary for antibiotic-inducible gene expression. A survey for… CONTINUE READING
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