Antibiotic-induced release of endotoxin: a reappraisal.

@article{Hurley1992AntibioticinducedRO,
  title={Antibiotic-induced release of endotoxin: a reappraisal.},
  author={James C Hurley},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1992},
  volume={15 5},
  pages={
          840-54
        }
}
A three- to 20-fold increase in the total concentration of endotoxin occurs as a consequence of antibiotic action on gram-negative bacteria both in vitro and in vivo. There is considerable overlap between the effect of beta-lactam antibiotics and non-beta-lactam antibiotics. Moreover, there is an unexplained delay between the lethal activity of antibiotics and the release of endotoxin. Hence, the mechanism whereby antibiotic action leads to the release of endotoxin is unclear, and mechanisms… CONTINUE READING
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